Preparation of lymphatic targeting dosage form: pingyangmycin absorbed on activated carbon nanoparticles.
- Author:
Ming-lei SUN
1
;
Yu-ming WEN
;
Chang-mei WANG
;
Long-jiang LI
;
Xiao-yi WANG
Author Information
- Publication Type:Journal Article
- MeSH: Antibiotics, Antineoplastic; administration & dosage; pharmacokinetics; Bleomycin; administration & dosage; analogs & derivatives; pharmacokinetics; Carbon; chemistry; Carcinoma, Squamous Cell; drug therapy; secondary; Humans; Injections, Intralymphatic; Lymph Nodes; drug effects; pathology; Lymphatic Metastasis; Mouth Neoplasms; drug therapy; pathology; Nanoparticles; Neck
- From: West China Journal of Stomatology 2004;22(3):183-185
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare anticancer nanoparticles for targeting therapy for oral cancer lymph node metastasis.
METHODSThe activated carbon nanoparticles (CH-NP) were prepared for drug carrier. Pingyangmycin (PYM), a high sensitive anticancer drug for oral squamous cell carcinoma, were selected as model drug. The activated carbon nanoparticles and PYM were mixed with saline and shaken 20 minutes so that PYM was absorbed on activated carbon enough, resulting in a new formulation of PYM (PYM-CH-NP). The absorbency of PYM on activated carbon nanoparticles was evaluated.
RESULTSThe diameter distribution for CH-NP ranged form 136 nm, to 540 nm, the average diameter was 176 nm. The proportion of CH-NP to PYM was increased and more absorbency of PYM on activated carbon nanoparticles was achieved.
CONCLUSIONThe activated carbon nanoparticles has high absorbency of PYM. The new formulation PYM-CH-NP can be used as targeting therapy of cervical lymph node metastasis by peri-cancer submucosal injection.
