Recombinant human BMP-2 accelerates bone formation of mandibular distraction osteogenesis in rabbits.
- Author:
Zhi-guo WANG
1
;
Jing HU
;
Shu-jian ZOU
;
Ji-Hua LI
;
Zhan-wei GAO
;
Da-zhang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; administration & dosage; pharmacology; Bone Regeneration; drug effects; Calcification, Physiologic; drug effects; Collagen; metabolism; Female; Male; Mandible; diagnostic imaging; drug effects; ultrastructure; Osteogenesis; Osteogenesis, Distraction; Rabbits; Radiography; Recombinant Proteins; administration & dosage; pharmacology; Transforming Growth Factor beta; administration & dosage; pharmacology
- From: West China Journal of Stomatology 2004;22(3):186-188
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of rhBMP-2 on bone formation of mandibular distraction osteogenesis in rabbits.
METHODSBilateral mandibular osteotomies were performed in 12 mature rabbits. 5 mg rhBMP-2 with the collagen carrier was implanted in the osteotomy site of one side of the mandibles. Only the collagen sponge was placed in the contra-lateral side as control. The mandibles of 8 rabbits were lengthened by 6mm using a custom-made distractor. At 4 weeks after the end of distraction, all animals were killed and the distracted calluses were harvested and processed for histological, scanning electron microscopic, as well as Ca/P ratio analysis.
RESULTSThe regenerated bone was found in the distraction gap after mandibular lengthening. The mandibular side treated with rhBMP-2 had greater amounts of new bone formation and earlier mineralization than contra-lateral side (non-rhBMP-2 treated).
CONCLUSIONRecombinant human BMP-2 appears to be able to accelerate bone formation of mandibular distraction osteogenesis in rabbits.
