The effect of intraperitoneal heparin on distribution of ACC-M in lung and liver.
- Author:
Xin-jun WANG
1
;
Wan-tao CHEN
;
Zheng-yan ZHOU
;
Yan-qing MA
;
Xiao-jian ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Carcinoma, Adenoid Cystic; pathology; Cell Adhesion; drug effects; Cell Line, Tumor; Female; Heparin; administration & dosage; pharmacology; Injections, Intraperitoneal; Liver; drug effects; pathology; Lung; drug effects; pathology; Mice; Mice, Inbred BALB C; Mice, Nude; Random Allocation; Salivary Gland Neoplasms; pathology
- From: West China Journal of Stomatology 2004;22(3):246-247
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of intraperitoneal heparin on the adhesion of highly lung metastasic adenoid cystic carcinoma cell line (ACC-M) in lung.
METHODS3HTdR labeled ACC-M cells were injected by intravenous infusion after intraperitoneal injection with 200 units heparin. 4 mice of each group were killed at 2 h, 6 h and 18 h after infusion. The relative radioactivity (CPM) in lung and liver was detected.
RESULTS3H-activity per gram in lung of heparin group was lower than control at the same time. There was significant difference between the two groups (P < 0.001). There was no difference between the two groups in liver (P > 0.05).
CONCLUSIONThe results of this study suggest that the highly lung metastasis characteristic of ACC-M may be partially inhabited by the use of intraperitoneal heparin.
