Kappa-opioid receptor stimulation contributes to aortic artery dilation through activation of K(ATP) channel in the rats.
- Author:
Jian-Ming PEI
1
;
Mai CHEN
;
Yao-Min WANG
;
Jun WEN
;
Yun-Long ZHU
Author Information
1. Department of Physiology, The Fourth Military Medical University, Xi an 710032. jmpei@fmmu.edu.cn
- Publication Type:Journal Article
- MeSH:
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer;
pharmacology;
Animals;
Aorta;
physiology;
In Vitro Techniques;
KATP Channels;
metabolism;
Male;
Rats;
Rats, Sprague-Dawley;
Receptors, Opioid, kappa;
agonists;
physiology;
Vasodilation;
physiology
- From:
Acta Physiologica Sinica
2003;55(1):91-95
- CountryChina
- Language:English
-
Abstract:
To investigate the relaxation effect and underlying mechanism of U50,488H (a selective kappa-opioid receptor agonist) on aorta in the rat, isolated aortic ring was perfused and the tension of the vessel was measured. It was shown: (1) kappa-opioid receptor stimulation with U50,488H relaxed rat aorta dose-dependently; (2) the relaxation effect of U50,488H on aorta was partially endothelium-dependent; (3) the relaxation effect of U50,488H was significantly attenuated in the presence of glybenclamide and glipizide, two ATP-sensitive K(+) channel (K(ATP)) blockers; and (4) the relaxation effect of U50,488H on vessel bore no relationship to muscarinic-receptor, beta-adrenoceptor, prostaglandin and nitric oxide (NO). These results indicate that kappa-opioid receptor stimulation with U50,488H relaxes the aortic artery at least partially via K(ATP) channel in the rat.
