Effect of tumor necrosis factor-alpha on differentiation of mesencephalic neural stem cells and proliferation of oligodendrocytes in the rat.
- Author:
Shu-Jie LOU
1
;
Ping GU
;
He XU
;
Xiao-Hui XU
;
Ming-Wei WANG
;
Cheng HE
;
Chang-Lin LU
Author Information
1. Department of Neurobiology, Second Military Medical University, Shanghai, PR China. loushjie@hotmail.com
- Publication Type:Journal Article
- MeSH:
Animals;
Animals, Newborn;
Astrocytes;
cytology;
Cell Differentiation;
physiology;
Cell Proliferation;
Mesencephalon;
cytology;
Neural Stem Cells;
cytology;
Neurons;
cytology;
Oligodendroglia;
cytology;
Rats;
Rats, Sprague-Dawley;
Tumor Necrosis Factor-alpha;
physiology
- From:
Acta Physiologica Sinica
2003;55(2):183-186
- CountryChina
- Language:Chinese
-
Abstract:
To observe the influence of tumor necrosis factor-alpha (TNF-alpha) on differentiation of rat mesencephalic neural stem cells (NSCs), the numbers of neurons, astrocytes and oligodendrocytes generated from NSCs were analyzed after differentiation for 3 days by using immunocytochemistry technique. The results show that: (1) TNF-alpha enhanced the proportions of neurons and oligodendrocytes in progeny of NSCs; and (2) TNF-alpha induced the proliferation of oligodendrocytes derived from NSCs, but the proliferation of astrocytes was not influenced by TNF-alpha. We conclude that the TNF-alpha could influence the application of NSCs.
