Intrarenal artery injection of L-arginine inhibits spontaneous activity of renal afferent nerve fibers.
- Author:
Hui-Juan MA
1
;
Yi-Xian LIU
;
Yu-Ming WU
;
Rui-Rong HE
Author Information
1. Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, PR China.
- Publication Type:Journal Article
- MeSH:
Animals;
Arginine;
administration & dosage;
pharmacology;
Depression, Chemical;
Electrophysiological Phenomena;
Female;
Injections, Intra-Arterial;
Kidney;
innervation;
Male;
Nerve Fibers;
drug effects;
physiology;
Rabbits;
Renal Artery;
Visceral Afferents;
physiology
- From:
Acta Physiologica Sinica
2003;55(2):225-231
- CountryChina
- Language:English
-
Abstract:
The purpose of this study was to determine the effect of intrarenal artery injection of L-arginine on multi- and single-unit spontaneous discharges of renal afferent nerve fibers in anesthetized rabbits. The results obtained are as follows: (1) intrarenal artery injection of L-arginine (0.05, 0.24, and 0.48 mmol/kg) decreased the renal afferent nerve activity (ARNA) in a dose-dependent manner with arterial pressure unchanged; (2) pretreatment with a nitric oxide synthase inhibitor L-NAME (N6-nitro-L-arginine methylester, 0.11 mmol/kg), completely abolished the effect of L-arginine; and (3) intrarenal artery injection of a nitric oxide donor SIN-1 (3-morpholinosydnonimine, 3.75 micromol/kg) also resulted in an inhibition of ARNA. The results suggest that intrarenal artery injection of NO precursor (L-arginine) and donor (SIN-1) can inhibit ARNA in anesthetized rabbits.
