Study on ability of chomosome mutation of aslem.
- Author:
Bao Van Trinh
- Publication Type:Journal Article
- Keywords:
aslem
- MeSH:
Mutation;
Pharmaceutical Preparations;
drug therapy
- From:Pharmaceutical Journal
1999;281(9):9-12
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
ASLEM is an immuno-stimulant produced by Hanoi college of Pharmacy. Chromosome mutagenicity of ASLEM was evaluated in bone marrow cells and testicular cells of 30 male mice. Male mice were treated with two similar dose of 0,06 mg/day of ASLEM or with saline (control). Chromosome preparations were made 24 h after 2nd injection of ASLEM or saline. 40 metaphases from the bone marrow cells and 20 duskiness metaphases from the testicular cells were analyzed. Frequency of cells with both numerical and structural chromosome aberrations in both bone marrow and testicular cells of ASLEM treated mice showed no significant difference than that found in the control.
