Expression of urotensin II and G-protein coupled receptor 14 mRNA in human pheochromocytoma tissues.
- Author:
Guo-Qiang LIU
1
;
Zheng-Pei ZENG
;
Han-Zhong LI
;
Xin-Rong FAN
;
Dong-Mei LIU
;
An-Li TONG
;
Xin ZHENG
;
Chang LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adrenal Cortex; metabolism; Adrenal Gland Neoplasms; metabolism; Adrenal Medulla; metabolism; Humans; Pheochromocytoma; metabolism; RNA, Messenger; biosynthesis; genetics; Receptors, G-Protein-Coupled; biosynthesis; genetics; Urotensins; biosynthesis; genetics
- From: Acta Academiae Medicinae Sinicae 2005;27(4):457-460
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of urotensin II (U II) and G-protein coupled receptor 14 (GPR14) mRNA in human pheochromocytoma tissues.
METHODSTotal RNA from normal adrenal and pheochromocytoma tissues was extracted. The reverse transcription-polymerase chain reaction method was used to evaluate the levels of U II and GPR14 mRNA expression in human pheochromocytoma tissues.
RESULTSThere was no significant difference of U II and GPR14 mRNA expression between normal adrenal cortex and medulla. The expression of U II and GPR14 mRNA in pheochromocytoma was significantly lower than that in normal adrenal cortex and medulla (P < 0.05). The expression of GPR14 mRNA in adrenal pheochromocytomas was significantly lower than that of extra-adrenal pheochromocytomas (P < 0.05).
CONCLUSIONU II and GPR14 may play a role in the pathogenesis and hypertension regulating of pheochromocytoma.
