Expression of monocyte chemoattractant protein-1 and lupus nephritis.
- Author:
Zhong-Juan LIU
1
;
Jia-You LIN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Arthritis, Rheumatoid; metabolism; Chemokine CCL2; biosynthesis; genetics; Female; Humans; Lupus Erythematosus, Systemic; metabolism; Lupus Nephritis; metabolism; Male; Middle Aged; RNA, Messenger; biosynthesis; genetics
- From: Acta Academiae Medicinae Sinicae 2005;27(4):491-495
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the role of monocyte chemoattractant protein-1 (MCP-1) in lupus nephritis (LN).
METHODSSera MCP-1 levels were measured by enzyme linked immunosorbent assay in 112 patients with systemic lupus erythematosus (SLE), 30 patients with rheumatoid arthritis, 11 non-SLE patients with renal impairment, and 40 healthy volunteers. MCP-1 mRNA expression in peripheral blood mononuclear cells (PBMCs) was also investigated with reverse trancription-polymerase chain reaction semi-quantitative method.
RESULTSThe expression of MCP-1 was significantly higher in active LN groups than in all other groups (P < 0.001), and there was a close correlation between MCP-1 expression and the overall SLE disease activity index score (r=0.6245, P < 0.001) and the SLE disease activity index renal score (r=0.6808, P < 0.001). Low expression of MCP-1 was observed in diseased controls and healthy controls. The sera levels of MCP-1 were significantly higher in patients with active diseases than in patients with inactive SLE and controls, but no significant difference were found between the active LN groups and non-renal involvement group (P >0.05).
CONCLUSIONThe expression of PBMCs MCP-1 mRNA is upregulated in active SLE. Meanwhile, its expression levels are correlated with the activity of LN.
