Endothelin signaling in cardiac myocyte.
- Author:
An-Jing REN
1
;
Wen-Jun YUAN
Author Information
1. Department of Physiology, Second Military Medical University, Shanghai 200433, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Endothelin-1;
physiology;
Endothelins;
physiology;
Humans;
Mitogen-Activated Protein Kinases;
metabolism;
Myocardial Contraction;
drug effects;
Myocytes, Cardiac;
metabolism;
Phosphatidylinositol 3-Kinases;
metabolism;
Protein Kinase C;
metabolism;
Signal Transduction
- From:
Acta Academiae Medicinae Sinicae
2005;27(4):529-533
- CountryChina
- Language:Chinese
-
Abstract:
Endothelin can affect the contractile properties of cardiacmyocyte, stimulate myocyte growth and myofibrillogenesis, and increase resistance to apoptosis by intracellular signaling pathways. This article briefly reviews the regulative effects of these signaling pathways including protein kinase C, mitogen activated protein kinase, and phosphoinositide 3'-OH kinase/protein kinase B.
