A novel hormone found in circulation--endogenous ouabain.
- Author:
Yan-Ping REN
1
;
Zhuo-Ren LÜ
Author Information
1. Department of Geriatric Cardiovascular Diseases, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
- Publication Type:Journal Article
- MeSH:
Adrenal Cortex;
metabolism;
Animals;
Antibodies;
therapeutic use;
Humans;
Hypertension;
etiology;
Nephrotic Syndrome;
etiology;
Ouabain;
immunology;
pharmacology;
Sodium-Potassium-Exchanging ATPase;
immunology;
physiology
- From:
Acta Academiae Medicinae Sinicae
2005;27(4):534-538
- CountryChina
- Language:Chinese
-
Abstract:
Endogenous ouabain (EO) is a recently found hormone that may be secreted from adrenal cortex. As an endogenous mammalian analogue of cardiac glycosides and an inhibitor of the sodium pump, it regulates the body fluid balance, urine sodium extraction and vasoconstrictive tone, and thus plays an important role in the pathogenesis of hypertension and some other cardiovascular disorders. This articke reviews its biological features, receptor and antibody, detection, effects on diseases and relationship with endothelial cells.
