Cytochrome P450/epoxyeicosatrienoic acids system and myocardial ischemic-reperfusion injury.
- Author:
Li-Ke ZHANG
1
;
Chao-Shu TANG
Author Information
1. Department of Pathophysiology, Capital University of Medical Sciences, Beijing 100054, China. bingshen@cpums.edu.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Cytochrome P-450 Enzyme System;
metabolism;
Eicosapentaenoic Acid;
metabolism;
Humans;
Mixed Function Oxygenases;
metabolism;
Myocardial Reperfusion Injury;
etiology;
metabolism
- From:
Acta Academiae Medicinae Sinicae
2005;27(4):539-542
- CountryChina
- Language:Chinese
-
Abstract:
Interests on the effects of cytochrome P450 (CYP450) monooxygenases and epoxyeicosatrienoic acids (EETs) on myocardial ischemic-reperfusion injury has been increased in recent years. The CYP450/EET system may influence the degree of myocardial ischemic-reperfusion injury through "poly-targets", such us oxygen free radical, calcium overload, leukocytes adherence, nitric oxide, ATP-sensitive K+ channels, and mitogen activated protein kinase. The exaggeration or recovery of injury depends on the physical status. Study of factors that affects CYP450/EET, particularly identification of their involvement in cardioprotective signaling and specific roles, will elucidate the mechanisms of myocardial ischemic-reperfusion injury, and find a new way of prevention and treatment. This article will review the relationship between the changes of CYP450/EETs system and myocardial ischemic-reper-
