Clinicopathological study of lymphatic vessel density and distribution in pancreatic cancer.
- Author:
Gang JIN
1
;
Xian-gui HU
;
Rui LIU
;
Yi-jie ZHANG
;
Cheng-hao SHAO
;
Yan TANG
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; pathology; Adult; Aged; Aged, 80 and over; Female; Humans; Immunohistochemistry; Lymph Nodes; pathology; Lymphatic Metastasis; Lymphatic Vessels; pathology; Male; Middle Aged; Pancreatic Neoplasms; pathology
- From: Acta Academiae Medicinae Sinicae 2005;27(5):583-586
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo clarify the clinicopathological significance of lymphatic vessel density (LVD) and distribution in pancreatic cancer.
METHODSWe measured LVD in 43 pancreatic cancer specimens by immunostaining with specific lymphatic endothelium marker, and examined their relationship with well-defined clinicopathological variables.
RESULTSIntratumoral LVD (9.4 +/- 10.0) was significantly lower than periturmoral (16.0 +/- 9.7) (P < 0.001) and nontumoral LVD (13.5 +/- 6.0) (P < 0.01). Increased peritumoral LVD correlated significantly with tumor staging (P < 0.05) and lymph node involvement (P < 0.05).
CONCLUSIONThe lymphatic vessels distribution in pancreatic cancer samples and peritumoral lymphangiogenesis may promote the malignant progression and lymph node metastasis of pancreatic cancer.
