Association between genetic polymorphisms in methylentetrahydrofolate reductase and risk of lung cancer.
- Author:
Xue-mei ZHANG
1
;
Xiao-ping MIAO
;
Wen TAN
;
Shi-ning QU
;
Tong SUN
;
Yi-feng ZHOU
;
Dong-xin LIN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Lung Neoplasms; enzymology; genetics; Male; Methylenetetrahydrofolate Reductase (NADPH2); genetics; Middle Aged; Polymorphism, Genetic; Risk
- From: Acta Academiae Medicinae Sinicae 2005;27(6):700-703
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between methylentetrahydrofolate reductase (MTHFR) polymorphisms and risk of lung cancer.
METHODSTotally 505 cases with lung cancer and 500 frequency-matched controls were genotyped for the MTHFR C677T and A1298C polymorphisms by polymerase chain reaction-restriction fragment length polymorphism methods. The odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression model. Haplotype frequency was estimated using EH software.
RESULTSThe frequency of the MTHFR C677T allele in cases was significantly higher than that in controls (53.5% vs 44.9%, P < 0.001). Compared with the 677CC genotype, the 677CT and 677TT genotypes were associated with increased risk of lung cancer, with the OR being 1.43 (95% CI, 1.04-1.95) and 2.40 (95% CI, 1.61-3.59), respectively. In addition, a significant difference in the distribution of haplotype frequencies between cases and controls was observed.
CONCLUSIONFunctional polymorphism in MTHFR is associated with increased risk of lung cancer in Chinese population.
