Haplotype and linkage analysis of HLA-I classical genes in Chinese Han population.
- Author:
Fang YUAN
1
;
Yu-Ying SUN
;
Yuan LUO
;
Fei LIANG
;
Nan LIU
;
Li JIN
;
Jin-Feng LIU
;
Shu-Guang LIU
;
Yong-Zhi XI
Author Information
1. Department of Immunology and National Center of Biomedicine Analysis, The Hospital Affiliated to Academy of Military Medical Sciences, Beijing 100071, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Asian Continental Ancestry Group;
genetics;
China;
ethnology;
Female;
HLA-A Antigens;
genetics;
HLA-B Antigens;
genetics;
HLA-C Antigens;
genetics;
Haplotypes;
Humans;
Linkage Disequilibrium;
Male;
Middle Aged;
Polymorphism, Genetic
- From:
Journal of Experimental Hematology
2007;15(5):1084-1089
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to investigate the parameters of gene frequencies, haplotype frequencies and linkage disequilibrium of HLA-A, -B, -Cw in HLA classical I loci for Chinese Han population. HLA-A, HLA-B and HLA-Cw loci were genotyped in 1014 unrelated China people using low resolution PCR-SSP typing method, and their genetic parameters were analyzed by statistic methods. The results indicated that among all the detected HLA-I genes, A*02 (0.33), A*11 (0.24), B*15 (0.14), B*13 (0.13), Cw*03 (0.25) and Cw*07 (0.18) were the popular gene groups distributing in Chinese Han population, and A*02-B*46 (0.071), A*11-B*15 (0.051), A*02-Cw*01 (0.084), A*11-Cw*03 (0.079), B*46-Cw*01 (0.095) and B*13-Cw*03 (0.071) were the predominant haplotypes in Han population. Additionally, A*02-B*46, A*30-B*13, A*30-Cw*06, A*02-Cw*01, B*46-Cw*01 and B*58-Cw*03 were statistically significant with strong linkage disequilibrium. While A*02-B*15, A*02-B*40, A*24-Cw*03, A*02-Cw*03 and A*31-Cw*03 were in low linkage disequilibrium, among them A*24-Cw*03 appeared frequently in HLA recombination events. In addition, A*02-B*46-Cw*01 (0.075), A*30-B*13-Cw*06 (0.046), A*11-B*13-Cw*03 (0.045), A*33-B*58-Cw*03 (0.044), A*11-B*15-Cw*08 (0.027), A*02-B*38-Cw*07 (0.023) and A*11-B*40-Cw*07 (0.022) were the main extended haplotypes in Han population. In conclusions, this study investigated systematically the genetic polymorphism features of Chinese Han population, which may provide useful genetic parameters for researches in colonial evolution, clinical transplantation and disease susceptibility.
