Correlation of HLA-alleles with aplastic anemia.
- Author:
Xiao-Lan LIANG
1
;
Lu-Gui QIU
;
Le-Jing SUN
;
Li-Jia YU
;
Jun-Ling HAN
;
Qian LI
Author Information
1. Institute of Hematology, Blood Disease Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin 300020, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Alleles;
Anemia, Aplastic;
genetics;
immunology;
Biomarkers;
Child;
Child, Preschool;
Female;
HLA-A Antigens;
genetics;
HLA-B Antigens;
genetics;
HLA-DR Antigens;
genetics;
HLA-DRB1 Chains;
Humans;
Male;
Young Adult
- From:
Journal of Experimental Hematology
2007;15(6):1208-1211
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the correlation between the HLA genes and pathogenesis of aplastic anemia (AA), polymerase chain reaction with specific sequence primers (PCR-SSP) method was used to HLA typing in 82 patients with AA and 400 normal healthy individuals as control. The results showed that A*2301 (1.84%), B*5501 (4.36%) and DRB1*0901 (23.48%) gene frequency in AA patients were significantly higher than those in controls (relative risk: RR=5.0253, 3.3645, 2.1269, chi2=4.6634, 6.3120, 9.1511 respectively) (p<0.01). In contrast, DRB1*1301 (1.23%) gene frequency was significantly lower in AA than that in controls, RR=0.2257, chi2=6.6629 (p<0.01). It is concluded that A*2301, B*5501 and DRB1*0901 genes may be considered as the risk markers while DRB1*1301 gene as a protective marker of AA.
