Analysis on prognosis and correlative factors of acute nonlymphocytic leukemia.
- Author:
Chun-Yan LIU
1
;
Rong FU
;
Wen-Hui LIU
;
Yu-Qian CHENG
;
Wen-Xiu SONG
;
Li-Juan DU
;
Er-Bao RUAN
;
Li-Tong ZHANG
;
Xiao-Ming WANG
;
Yong LIANG
;
Guo-Jin WANG
;
Wen QU
;
Jia SONG
;
Rong-Li ZHANG
;
Jing GUAN
;
Li-Juan LI
;
Yang SONG
;
Shan GAO
;
Hui LIU
;
Hui-Juan JIANG
;
Jun WANG
;
Peng ZOU
;
Zong-Hong SHAO
Author Information
1. Department of Hematology, The General Hospital, Tianjin Medical University, Tianjin 300052, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Antineoplastic Combined Chemotherapy Protocols;
therapeutic use;
Cytarabine;
administration & dosage;
therapeutic use;
Female;
Harringtonines;
administration & dosage;
therapeutic use;
Humans;
Leukemia, Myeloid, Acute;
diagnosis;
drug therapy;
Male;
Middle Aged;
Prognosis;
Tretinoin;
administration & dosage;
therapeutic use;
Young Adult
- From:
Journal of Experimental Hematology
2007;15(6):1300-1304
- CountryChina
- Language:Chinese
-
Abstract:
To analyze the prognosis and risk factors of acute nonlymphocytic leukemia (ANLL), 94 patients with acute nonlymphocytic leukemia were enrolled in this study, while survival rate and risk factors of prognosis were analyzed. The results indicated that the complete remission (CR) ratio was 51.1%. Overall survival and event-free survival rates of month 6, 12, 18, 24 were 68.6%, 55.8%, 53.8%, 46.4%, 21.3% and 57.9%, 38.6%, 33.3%, 31.6%, 0% respectively. The factors such as age<40 years, WBC<10.0x10(9)/L before chemotherapy, WBC in the period of bone marrow suppression<1.0x10(9)/L, chemotherapy within 1 month after occurrence of leukemia, blood transfusion before chemotherapy of APL had favourable influence on remission and survival rates of ANLL patients. CR1, the time to get CR, length of CR and relapse significantly correlated with prognosis (p<0.05). It is concluded that the individualized therapy concerning the risk factors should be applied to ANLL patients for improving the remission, survival rate and prognosis.
