Resistance of leukemia cells to Fas/FasL-mediated apoptosis and strategies replying to antiapoptosis of leukemia cells--review.
- Author:
Li WANG
1
Author Information
1. Departmant of Hematology, Center Hospital of Wuhan, Wuhan 430014, China. zouping@public.wh.hb.cn
- Publication Type:Journal Article
- MeSH:
Apoptosis;
physiology;
CD28 Antigens;
metabolism;
Fas Ligand Protein;
physiology;
Humans;
Leukemia;
pathology;
Matrix Metalloproteinase 7;
metabolism;
NF-kappa B;
metabolism;
Tumor Cells, Cultured;
X-Linked Inhibitor of Apoptosis Protein;
metabolism;
fas Receptor;
physiology
- From:
Journal of Experimental Hematology
2007;15(6):1325-1329
- CountryChina
- Language:Chinese
-
Abstract:
At angle of cell apoptosis, the excessive less of hematopeitic cell apoptosis is a reason of hematopoietic cell accumulation. The Fas/FasL system as an important pathway inducing cell apoptosis participates in occurrence and development of leukemia. Leukemia cells generally are not sensitive or are resistant to Fas/FasL-mediated apoptosis, while it is one of important reasons resulting in immunoescape and unsensitivity of leukemia cells to chemotherapy. In recent years studies related to mechanisms of leukemia cell resistance to Fas/FasL-mediated apoptosis such as Fas and FasL mutation and expression abnormality, Fas signaling transduction pathway abnormality, and regulatory affect of apoptotic regulatory genes on Fas/FasL system, as well as strategies replying to antiapoptosis of leukemia cells including NF-kappab, XIAP, membrane receptor CD28 and matrix metalloproteinase 7 obtained some progresses. The above-mentioned issues were reviewed in this article.
