New insight into pathogenesis of idiopathic myelofibrosis--review.
- Author:
Zu-Qiong XU
1
;
Xue-Mei SUN
Author Information
1. Department Hematology, Nanjing Drum Tower-Hospital, Nanjing University Medical College, Nanjing 210008, China.
- Publication Type:Journal Article
- MeSH:
GABA Plasma Membrane Transport Proteins;
genetics;
Humans;
Janus Kinase 2;
genetics;
Mutation;
Primary Myelofibrosis;
etiology;
genetics;
Receptor Protein-Tyrosine Kinases;
genetics;
Receptors, Thrombopoietin;
genetics
- From:
Journal of Experimental Hematology
2007;15(6):1330-1334
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic myelofibrosis is a type of chronic myeloproliferative disorders characterized by splenomegaly, a leukoerythroblastic blood picture, teardrop poikilocytosis, in various degrees of bone marrow fibrosis and extramedullary hematopoiesis. In this paper, the biological characters and pathogenesis of idiopathic myelofibrosis such as mutation of tyrosine kinase receptor, mutation of GABA transporter 1, JAK2 mutation and c-MPl mutation, as well as other pathogenesis related with idiopathic myelofibrosis were reviewed.
