Characteristics of cases with chromosome 3q21q26 aberrations.
- Author:
Yan ZHANG
1
;
Qi HE
;
Yan SHI
;
Hui DANG
;
Jing-Ying QIU
;
Xiao-Jun HUANG
;
Dao-Pei LU
Author Information
1. Peking University People Hospital, Peking University Institute of Hematalogy, Beijing 100044, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Chromosome Inversion;
Chromosomes, Human, Pair 3;
genetics;
Chromosomes, Human, Pair 7;
genetics;
Female;
Humans;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
genetics;
Leukemia, Myeloid, Acute;
genetics;
Male;
Middle Aged;
Myelodysplastic Syndromes;
genetics;
Prognosis;
Translocation, Genetic;
Young Adult
- From:
Journal of Experimental Hematology
2008;16(1):22-25
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the cytogenetic and clinical characteristics of inv(3q) (q21q26) and t(3;3) (q21; q26) aberrations as well as prognosis, cases were collected and chromosome specimens of bone marrow cells were prepared by 24-hour culture, while G-banding technique was used to perform karyotyping. The results showed that the simple inv(3q) and t(3; 3) aberrations were rare, they commonly combined with other chromosome aberrations such as -7/7q- and t (9; 22). The involved diseases included myelodysplastic syndromes, acute myeloid leukemia and chronic myelogenous leukemia in blast crisis. Out of 24 patients, 2 patients diagnosed with M(5) subtype did not achieve complete remission after multiple chemotherapy; 2 patients received allogenic stem cell transplantation relapsed. It is concluded that 3q21q26 aberration commonly combined with chromosome aberration 7/7q-, for these patients the efficacy of chemical therapy is poor, the efficacy of bone marrow transplant is too poor, these patients with inv(3q) and t(3; 3) aberrations have poor prognosis and short overall survival.
