Pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A in Carthami Flos.
- Author:
Li XIA
1
;
Xiang-Mei CHEN
;
Li-Rong PENG
;
Shi-Xiang WANG
;
Xiao-Wen WANG
;
Yan ZUO
;
Peng ZHANG
;
Qin-She LIU
;
Xiao-Hui ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Animals; Caesalpinia; chemistry; Carthamus tinctorius; chemistry; Chalcone; administration & dosage; analogs & derivatives; isolation & purification; pharmacokinetics; Chromatography, High Pressure Liquid; Drug Synergism; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacokinetics; Female; Flowers; chemistry; Male; Quinones; administration & dosage; isolation & purification; pharmacokinetics; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Wood; chemistry
- From: China Journal of Chinese Materia Medica 2013;38(2):269-272
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A (HSYA) in Carthami Flos.
METHODConcentration of HSYA in rat plasma was detected by RP-HPLC after rats were orally administered with extracts of Carthami Flos or Carthami Flos combined with Sappan Lignum. Pharmacokinetic parameters were calculated by DAS 2.0 pharmacokinetic software.
RESULTIn vivo pharmacokinetic models of HSYA were two-compartment open models in both of the Carthami Flos group and the Carthami Flos combined with Sappan Lignum group. After compatibility, HSYA showed a significant lower in apparent volumes of distribution of t(1/2Ka), t(1/2alpha) and V1/F, with slight advance in T(max).
CONCLUSIONSappan Lignum can accelerate absorption, distribution and metabolic process of HSYA in vivo and reduce its accumulation in vivo.
