Chemical constituents of stems and leaves of Salvia yunnanensis and their anti-angiogeneic activities.
- Author:
Cheng XIANG
1
;
Lu-Ping ZHU
;
Wen-Ting ZHUANG
;
Lin-Dong ZHANG
;
Jing HE
;
Peng LI
;
Bao-Cai LI
Author Information
1. Kunming University of Science and Technology, Kunning 650500, China. xcheng0871@163.com
- Publication Type:Journal Article
- MeSH:
Angiogenesis Inhibitors;
chemistry;
pharmacology;
Animals;
Chorioallantoic Membrane;
drug effects;
metabolism;
Dose-Response Relationship, Drug;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
Plant Leaves;
chemistry;
Plant Stems;
chemistry;
Salvia;
chemistry
- From:
China Journal of Chinese Materia Medica
2013;38(6):835-838
- CountryChina
- Language:Chinese
-
Abstract:
Present study was focused on the chemical constituents of the stems and leaves of Salvia yunnanensis C . H. Wright and their anti-angiogeneic activities. The compounds were isolated by column chromatography over silica gel and Sephadex LH-20, and other isolation techniques. Their structures were elucidated on the basis of spectral analysis and chemical evidences. Their anti-angiogeneic activities were evaluated by the chicken chorioallantoic membrane (CAM) neovascularisation model. Seven compounds were separated and identified as ( + ) -spathulenol( 1), 5,7,4'-trihydroxyflavanone(2) , beta-amyrin(3), 3 beta-hydroxy-12-ursene(4), 2alpha,3 beta-dihydroxyursa-12-en-28-oic acid(5), ursolic acid (6) and 3-oxo-12-ursen-28-oic acid (7). Compounds 1, 2, 5 and 6 were obtained from this plant for the first time. Compounds 5 (an oleanane compound) and 6 (an ursane compound) could inhibit angiogenesis significantly in a dose-dependent manner.
