Polymorphisms of the CTLA-4 promoter(-318) and exon 1(+49) genes with atopic dermatitis in Korean children.
10.3345/kjp.2006.49.5.545
- Author:
Tae Won SONG
1
;
Hea Sun YANG
;
Kyung Eun LEE
;
Kyung Won KIM
;
Eun Soo KIM
;
Myung Hyun SOHN
;
Kyu Earn KIM
Author Information
1. Department of Pediatrics and Institute of Allergy, BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. mhsohn@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Atopic dermatitis;
CTLA-4;
Polymorphism
- MeSH:
Child*;
Dermatitis, Atopic*;
Eczema;
Eosinophils;
Exons*;
Gene Frequency;
Genotype;
Humans;
Immunoglobulin E;
Polymorphism, Restriction Fragment Length
- From:Korean Journal of Pediatrics
2006;49(5):545-551
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The gene-encoding cytotoxic T lymphocyte-associated antigen-4(CTLA-4) is one of the candidate genes for conferring susceptibility to atopic dermatitis(AD). The aim of the study was to investigate the association between Korean children with AD and the polymorphisms of CTLA-4 gene promoter(-318) and exon 1(+49). METHODS: The CTLA-4 promoter(-318 T/C) and exon 1(+49 A/G) polymorphisms were genotyped via restriction fragment length polymorphism methods in 145 children with atopic eczema, 69 children with non-atopic eczema, and 96 healthy controls. RESULTS: There was no significant difference in genotype and allele frequencies of the CTLA-4 promoter -318 T/C and exon 1 +49 A/G polymorphisms when the atopic eczema, non-atopic eczema, and control groups were compared. Additionally the CTLA-4 promoter -318 T/C and exon 1 +49 A/G polymorphisms were not shown to be associated with severity, IgE level, or eosinophil counts. CONCLUSION: Our data show that the polymorphisms within the CTLA-4 promoter(-318 T/C) and exon 1(+49 A/G) genes are not associated with susceptibility to AD in Korean children.
