Expressions of farnesoid X receptor and myeloid cell leukemia sequence 1 protein are associated with poor prognosis in patients with gallbladder cancer.

Wei WANG; Xiaobin YIN; Guiping LI; Jing YI; Jian WANG

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Expressions of farnesoid X receptor and myeloid cell leukemia sequence 1 protein are associated with poor prognosis in patients with gallbladder cancer.

Author: Wei WANG ¹ ; Xiaobin YIN ¹ ; Guiping LI ² ; Jing YI ² ; Jian WANG ¹
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1. Department of Biliary-Pancreatic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
2. Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Institutes of Medical Sciences, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Publication Type:Journal Article
MeSH: Adult; Aged; Aged, 80 and over; Disease Progression; Female; Gallbladder Neoplasms; diagnosis; metabolism; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; metabolism; Neoplasm Staging; Prognosis; Receptors, Cytoplasmic and Nuclear; metabolism
From: Chinese Medical Journal 2014;127(14):2637-2642
CountryChina
Language:English
Abstract:
BACKGROUNDFarnesoid X receptor (FXR) regulates tumorigenesis, but its clinical significance in gallbladder cancer (GBC) remains unclear. This study investigated its clinical and prognostic significance in GBC patients, as well as its association with the anti-apoptotic protein, myeloid cell leukemia sequence 1 (MCL1) protein.
METHODSFXR and MCL1 expression in 42 primary GBC and 15 normal gallbladder tissues were analyzed by immunohistochemistry. The patients and samples were collected from Ren Ji Hospital from January 2005 to December 2010. Their association with clinicopathologic factors and prognosis, as well as the correlation between FXR and MCL1 protein expression were analyzed by statistical analyses.
RESULTSCompared with normal gallbladder tissues, FXR expression was decreased and MCL1 expression was increased in GBC, during progression of tumor node metastasis (TNM) stage. The Kaplan-Meier survival analysis showed that FXR low-expression and MCL1 over-expression were significantly associated with overall poor survival. Furthermore, multivariate analysis showed that FXR and MCL1 are both prognostic factors for GBC patients. FXR low-expression was significantly correlated with MCL1 over-expression.
CONCLUSIONFXR might be a new molecular marker to predict the prognosis of patients with GBC and a novel therapeutic target.