Outcome of kidney transplantation between controlled cardiac death and brain death donors: a meta-analysis.

Yingzi Ming; Mingjie Shao; Tingting Tian; Xingguo She; Hong Liu; Shaojun YE; Qifa YE

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Outcome of kidney transplantation between controlled cardiac death and brain death donors: a meta-analysis.

Author: Yingzi MING ¹ ; Mingjie SHAO ¹ ; Tingting TIAN ² ; Xingguo SHE ¹ ; Hong LIU ¹ ; Shaojun YE ¹ ; Qifa YE ³
Author Information

1. Research Center of Chinese Health Ministry on Transplantation Medicine Engineering and Technology, the Third Affiliated Hospital, Central South University, Changsha, Hunan 410013, China.
2. Department of Radiology, the Third Affiliated Hospital, Central South University, Changsha, Hunan 410013, China.
3. Research Center of Chinese Health Ministry on Transplantation Medicine Engineering and Technology, the Third Affiliated Hospital, Central South University, Changsha, Hunan 410013, China. Email: yqf_china@163.com.
Publication Type:Journal Article
MeSH: Brain Death; Death; Humans; Kidney Transplantation; statistics & numerical data; Retrospective Studies; Tissue Donors
From: Chinese Medical Journal 2014;127(15):2829-2836
CountryChina
Language:English
Abstract:
BACKGROUNDOur goal was to evaluate the outcomes of kidney transplants from controlled cardiac death donors compared with brain death donors by conducting a meta-analysis of cohort studies.
METHODSThe PubMed database and EMBASE were searched from January 1980 to July 2013 to identify studies that met pre-stated inclusion criteria. Reference lists of retrieved articles were also reviewed. Two authors independently extracted information on the designs of the studies, the characteristics of the study participants, and outcome assessments.
RESULTSNine cohort studies involving 84 398 participants were included in this meta-analysis; 3 014 received kidneys from controlled cardiac death donors and 80 684 from brain death donors. Warm ischemia time was significantly longer for the controlled cardiac death donor group. The incidence of delayed graft function was 2.74 times (P < 0.001) greater in the controlled cardiac death donor group. The results are in favor of the brain death donor group on short-term patient and graft survival while this difference became nonsignificant at mid-term and long term. Sensitivity analysis yielded similar results. No evidence of publication bias was observed.
CONCLUSIONThis meta-analysis of retrospective cohort studies suggests that the outcome after controlled cardiac death donors is comparable with that obtained using kidneys from brain death donors.