Experimental drugs for treatment of autoimmune myocarditis.

Lina Han; Shuli Guo; Yutang Wang; Liming Yang; Siyu Liu

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Experimental drugs for treatment of autoimmune myocarditis.

Author: Lina HAN ¹ ; Shuli GUO ² ; Yutang WANG ¹ ; Liming YANG ¹ ; Siyu LIU ¹
Author Information

1. First Department of Cardiovascular Internal Medicine, Nanlou Branch of Chinese People's Liberation Army General Hospital, Beijing 100853, China.
2. School of Automation, Beijing Institute of Technology, Beijing 100081, China. Email: guoshuli@bit.edu.cn.
Publication Type:Journal Article
MeSH: Animals; Autoimmune Diseases; drug therapy; Drugs, Investigational; therapeutic use; Humans; Medicine, Chinese Traditional; Myocarditis; drug therapy; Therapies, Investigational; trends
From: Chinese Medical Journal 2014;127(15):2850-2859
CountryChina
Language:English
Abstract:
OBJECTIVETo review the experimental drugs for the treatment of autoimmune myocarditis.
DATA SOURCESThe literatures published in English about different kinds of experimental drugs based on different therapeutic mechanisms for the treatment of autoimmune myocarditis were obtained from PubMed from 2002 to 2013.
STUDY SELECTIONOriginal articles regarding the experimental drugs for treatment of autoimmune myocarditis were selected.
RESULTSThis study summarized the effects of the experimental drugs for the treatment of autoimmune myocarditis, such as immunomodulators and immunosuppressants, antibiotics, Chinese medicinal herbs, cardiovascular diseases treatment drugs, etc. These drugs can significantly attenuate autoimmune myocarditis-induced inflammation and fibrosis, alleviate autoimmune myocarditis-triggered overt lymphocyte proliferation, and meanwhile reduce Th1 cytokines (IFN-γ and IL-2) and increase Th2 cytokines (IL-4 and IL-10).
CONCLUSIONThis study summarized recent advances in autoimmune myocarditis treatment and further proposes that traditional Chinese medicine and immune regulators will play important roles in the future.