Relation between uric acid and coronary artery calcification:a community-based cross-sectional survey among Beijing natural population.
- Author:
Hui-Li CAO
1
;
Bin LV
;
Xiong-biao CHEN
;
Jin-guo LU
;
Zhi-hui HOU
;
Xiang TANG
;
Yang GAO
;
Fang-fang YU
;
Yang CHEN
;
Shi-liang JIANG
;
Lian-cheng ZHAO
;
Ying LI
;
Dong-feng GU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; China; epidemiology; Coronary Artery Disease; blood; epidemiology; pathology; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Prevalence; Risk Factors; Uric Acid; blood; Vascular Calcification; epidemiology
- From: Chinese Journal of Epidemiology 2013;34(6):566-568
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the influence of uric acid on coronary artery calcification in the natural population in Beijing.
METHODSFrom April to July 2012, 903 subjects from the natural population(aged 37-76 years for men, aged 42-76 years for women)in Xishan community, Beijing, were selected to accept a survey on the risk factors of cardiovascular. Blood tests and CT coronary artery calcium scans were carried out.
RESULTSAt the 1 Quartile(1 Q), 2 to 3 Quartile(2-3 Q)and 4 Quartile(4 Q)of uric acid levels, the prevalence rates of coronary artery calcium were 37.2% , 45.5% , 60.6% (P<0.001) and the coronary artery calcium scores were (109.7±333.1)AU, (133.9±356.9)AU, (200.8±459.4) AU (P < 0.001)respectively. Data from the univariate logistic regression analysis showed that with the increase of uric acid, the prevalence rates of coronary artery calcium also increased(OR2-3Q = 1.41, 95% CI:1.02-1.95, P = 0.040; OR4Q = 2.60, 95% CI:1.78-3.80, P < 0.001). However, the relationship between uric acid and coronary artery calcium disappeared when using the multivariate logistic regression analysis(OR2-3Q = 0.92, 95% CI: 0.60-1.43, P = 0.713;OR4Q = 1.38, 95% CI:0.80-2.39, P = 0.247).
CONCLUSIONUric acid did not seem to be an independent risk factor for coronary artery calcium, although the prevalence and extent of coronary artery calcium increased along with the increasing trend of uric acid.
