Expression of E-cadherin and uPA and their prognostic value in carcinoma of human larynx
10.3760/cma.j.issn.1673-0860.2009.12.014
- VernacularTitle:喉癌组织中细胞黏附分子和尿激酶型纤溶酶原激活剂的表达及在预后评估中的价值
- Author:
Hai-Yan WU
1
;
Xiao-Hui SHEN
;
Rong-Sheng NI
;
Xiao-Yun QIAN
;
Xia GAO
Author Information
1. 东南大学医学院附属江阴医院
- Keywords:
Laryngeal neoplasms;
Cadherins;
Urinary plasminogen;
Prognosis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2009;44(12):1024-1028
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of E-cadherin(ECD)and uPA in laryngeal cancer and evaluate their clinical value in prognosis.Methods ECD and uPA were determined by immunohistochemistry of Envision methods in carcinoma tissues of 51 patients of laryngeal carcinoma.All patients were followed and the prognostic factors were analyzed.Results Among 51 patients'tumor tissues,24(47.1%)were negative expression of ECD,and 26(51.0%)were positive uPA immunoreaction was observed.There were four subgroups of patterns of ECD and uPA expression:14(27.1 %)ECD-positive/uPA-negative,13(25.5%)ECD-negative/uPA-negative,11(21.6%)ECD-positive/uPA-positive,and 13(25.5%)ECD-negative /uPA-positive.The tumor tissues with ECD-negative and uPA-positive expression were significant associated with lymph nodes metastasis(X~2=5.545,5.79,P=0.019,0.016 respectively).Patients with ECD-negative expression had a shorter survival than the patients with ECD positive expression but no statistic difference(X~2=2.534,P＞0.05).Patients with uPA-positive expression had a significantly shorter survival time than those with uPA-negative expression(X~2=6.259,P＜0.05).There was a difference for the median survival time between the patients with uPA-negative/ECD-positive and the patients with uPA-positive/ECD-negative in laryngeal cancer tissue(X~2=6.559,P=0.01),and the survival curves between these two groups was also statistically significant difference.Multivariate analysis of Cox revealed that clinical stage and ECD/uPA(P=0.009,0.007 respectively)were two independent prognostic factors.Conclusions The combination analysis of uPA and ECD immunohistochemical expression in the laryngeal cancer tissue may be useful for predicting tumor metastatic risks and patient's prognosis.
