A comparative study of sentinel lymph node detection in laryngeal and hypopharyngeal carcinoma by lymphoscintigraphy method and blue dye
10.3760/cma.j.issn.1673-0860.2010.01.011
- VernacularTitle:淋巴显像法与染料法示踪喉癌和下咽癌前哨淋巴结的对比研究
- Author:
Yan CHENG
1
;
Bin-Quan WANG
;
Si-Jin LI
;
Shu-Xin WEN
;
Li-Jun XIA
;
Xian-Feng LI
;
De-Shan ZHAO
Author Information
1. 山西医科大学第一医院
- Keywords:
Sentinel lymph node biopsy;
Laryngeal neoplasms;
Hypopharyngeal neoplasms;
Lymphography;
Staining and labeling
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2010;45(1):42-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of sentinel lymph node (SLN) detection in laryngeal and hypopharyngeal carcinoma patients with clinically negative neckk (cNO) by lymphoscintigraphy method and blue dye. Methods Forty patients with cNO laryngeal neoplasms and ten patients with cNO hypopharyngeal carcinoma scheduled for tumor resection and neck dissection, were eligible for the study.single photon emission computed tomography (SPECT)/CT lymphoscintigraphy was performed with injection of radioactivity isotope ~(99)Tc~m labeled sulfur colloid(~(99)Tc~m-SC). Methylthioninium was injected into the same paints as ~(99)Tc~m-SC during surgery, and the patients underwent lymphatic mapping with a handheld gamma-detecting probe. All removed lymph nodes were examined by routine histopathology. Results Thirty-five patients with laryngeal carcinoma and six patients with hypopharyngeal carcinoma detected SLN by radiolabeled tracer method, the detection rate of SLN was 82.0%.Tnenty-nine patients with laryngeal carcinoma and 4 patients with hypopharyngeal carcinoma detected SLN by blue dye method, the detection rate of SLN was 66.0%. There were significant difference between two groups (χ~2=2.769, P<0.05), and the number of SLN were respectively 96 and 83 by radiolabeled tracer method and blue dye (χ~2=-2.098,P<0.05), The sensitivity of SLN detection were respectively 83.3% and 66.7%. Twelve (24.0%) patients had lymph node metastasis. Conclusions Either lymphoscintigraphy or blue dye mapping can be used to detect the SLN in cNO laryngeal and hypopharyngeal carcinoma. The lymphoscintigraphy not only preoperatively can locate the accuracy of SLN detection, but also has higher detection rate and sensitivity than dye method.
