Histopathological change of cricoarytenoid joint after laryngeal recurrent nerve paralysis in dogs
10.3760/cma.j.issn.1673-0860.2010.01.014
- VernacularTitle:犬喉返神经损伤后环杓关节组织病理学特性初步研究
- Author:
Hui-Ying HU
1
;
Wen XU
;
Er-Zhong FAN
;
Sheng-Zhong ZHANG
Author Information
1. 首都医科大学附属北京同仁医院
- Keywords:
Vocal cord paralysis;
Recurrent laryngeal nerve;
Articulation disorders;
Disease models,animal;
Dogs
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2010;45(1):56-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the histopathological changes in cricoarytenoid joints in 32 animal models.The characteristic histopathological changes of arytenoid cartilages after recurrent nerve paralysis were evaluated. Methods Sixteen dogs (32 vocal folds, 8 as normal control) were divided into different animal models of recurrent nerve paralysis as transection, haft-section, ligation, or crush. The histopathological finds of arytenoid cartilages were analysed.Results Arytenoid cartilages showed fibrin (12/24), disruption of the fibrous membrane(9/24), fibrillation (7/24) and degenerative changes in their joint surface structure (3/24) at various levels of intensity.The fibrin and disruption of the fibrous membrane were found 1 month after injury, and all changes appeared in 6 months. The fibrillation and arytenoid cartilages degenerative changes revealed in transaction group and ligation group, and became stronger in time of 6 months. The correlation among the fibrillation ratio and the normal control was positive ( t were 6.23 and 3.65, P<0.01 ). The correlation among the number of cellular of arytenoid cartilages and the normal control was positive (t= 2.78, P < 0. 05 ). The fibrillation (7) and arytenoid cartilages degenerative changes (3) revealed in vocal fold fixation to influence the recovery of laryngeal function.Conclusions The histopathological change of cricoarytenoid joint after recurrent nerve paralysis was related to the severity of neural injury. Influence the recovery of laryngeal function more often from 6 months.
