The preparation of bioglass/collagen/phosphoserine biomemetic composite scaffold and a study on its cytocompatibility.
- Author:
Xiaofeng CHEN
1
;
Xiangjun LI
;
Yingjun WANG
;
Chunrong YANG
;
Naru ZHAO
Author Information
1. Biomaterials Research Institute, College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China. chenxf@scut.edu.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Biocompatible Materials;
chemistry;
Biomimetic Materials;
chemical synthesis;
Cell Line;
Cell Proliferation;
Ceramics;
chemistry;
Collagen;
chemistry;
Mice;
Osteoblasts;
cytology;
Phosphoserine;
chemistry;
Tissue Engineering;
methods;
Tissue Scaffolds
- From:
Journal of Biomedical Engineering
2008;25(5):1112-1115
- CountryChina
- Language:Chinese
-
Abstract:
In the present study, novel biomemetic composite scaffolds using the sol-gel derived bioactive glass (BG), collagen (COL), and phosphoserine (PS) were prepared by freeze-drying. MC3T3-E1 were cultivated in vitro, collected and seeded onto the surface of BG, BG-COL and BG-COL-PS. Cell attachment and proliferation were observed. The cell proliferation was tracked by MTT method 1,3,5 d after seeding. MTT showed that the cells can adhere to and proliferate well on the surface of the scaffolds, and the cell proliferation result of scaffold BG-COL-PS was better than those of scaffolds BG and BG-COL. Therefore, the scaffold BG-COL-PS can be a potential scaffold for tissue engineer.
