Synthesis and characterization of thermosensitive hydrogel based on PEG-PCL-PEG block copolymers.
- Author:
Changyang GONG
1
;
Yingchun GU
;
Zhen XIE
;
Xihui XIE
;
Caibing LIU
;
Bing KAN
;
Mingjing TU
;
Yuquan WEI
;
Zhiyong QIAN
Author Information
1. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Biocompatible Materials;
chemical synthesis;
chemistry;
Drug Carriers;
chemistry;
Drug Delivery Systems;
Hydrogel, Polyethylene Glycol Dimethacrylate;
chemistry;
Polyesters;
chemical synthesis;
chemistry;
Polyethylene Glycols;
chemical synthesis;
chemistry;
Spectroscopy, Fourier Transform Infrared;
Temperature
- From:
Journal of Biomedical Engineering
2008;25(5):1121-1125
- CountryChina
- Language:Chinese
-
Abstract:
In this paper, a series of low-molecular-weight PEG-PCL-PEG triblock copolymers were successfully synthesized by ring-opening polymerization method, and were characterized using 1H-NMR and FTIR. The aqueous solution displayed specific thermosensitive gel-sol transition when the concentration was above corresponding critical gel concentration (CGC). The gel-sol phase diagram was recorded using test tube-inverting method, which was depended on the hydrophilic/hydrophobic balance in macromolecular structure, as well as heating history. As a result, the gel-sol transition temperature range could be altered, which might be very useful for its application as injectable drug delivery system.
