Preparation and biological safety evaluation of porous n-HA/PA66 composite.
- Author:
Hong LI
1
;
Yubao LI
;
Yonggang YAN
;
Gang ZHOU
;
Mingbo WANG
;
Lin CHENG
Author Information
1. Research Center for Nano-Biomaterials Center, Analytical and Testing Center, Sichuan University, Chengdu 610064, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Bone Substitutes;
chemical synthesis;
toxicity;
Durapatite;
chemistry;
Guinea Pigs;
Implants, Experimental;
Materials Testing;
Mice;
Nanocomposites;
chemistry;
Nanoparticles;
chemistry;
Nylons;
chemistry;
Porosity;
Rabbits;
Tissue Engineering
- From:
Journal of Biomedical Engineering
2008;25(5):1126-1129
- CountryChina
- Language:Chinese
-
Abstract:
Porous nano-hydroxyapatite/polyamide 66 (n-HA/PA66) composite was developed by injection molding method. Uniformly distributed and interconnected pores with an average size of about 500 microm in matrix were obtained. The evaluation of biological safety of the porous composite including cell cytoxicity test, sensitivity test, pyrogen test, haemolysis test was carried out according to GB/T16886 and GB/T16175. The results showed that the porous n-HA/PA66 composite was of no cytotoxicity, no allergen and pyrogen reactions as well as no hemolytic effect.
