The progress of research on low-frequency sonophoresis and its applications.
- Author:
Xi TU
1
;
Qinqin YIN
;
Wensheng ZHANG
;
Hua HUANG
Author Information
1. School of Medical Information Engineering, College of Electrical Engineering and Information, Sichuan University, Chengdu 610065, China.
- Publication Type:Journal Article
- MeSH:
Administration, Cutaneous;
Animals;
Humans;
Skin;
diagnostic imaging;
metabolism;
Skin Absorption;
radiation effects;
Ultrasonography
- From:
Journal of Biomedical Engineering
2008;25(6):1474-1478
- CountryChina
- Language:Chinese
-
Abstract:
Low-frequency ultrasound can increase the transdermal delivery of many drugs, including macromolecular drugs. The main mechanism is ultrasonic cavitation. Most researchers pointed out that it could change the form-structure of stratum corneum keratinocytes and, in this way, it can improve the permeability of skin. Low-frequency sonophoresis has been in use for in-vitro experiments and in-vivo animal experiments, and so far, both small-molecules transdermal delivery and macromolecules transdermal delivery have been successfully performed in many experiments. However, there are few reports about the real low-frequency sonophoresis for clinical treatment. A large number of clinical trials are necessary to confirm its safety and practicality. Once its safety is confirmed and the suitable low-frequency sonophoresis devices are developed successfully, Low-frequency Sonophoresis will come to be a safe, effective, controllable, and economic new delivery method.
