Clinical research of the relation of hepatitis B surface antigen (HBsAg) quantification and hepatic tissue pathological staging
10.3760/cma.j.issn.1003-9279.2013.01.014
- VernacularTitle:乙型肝炎表面抗原定量与肝组织病理关系的临床研究
- Author:
Xiu-Li YU
1
;
Jian-Chun GUO
;
Yun-Hao XUN
;
Wei-Zhen SHI
;
Yu-Fang WANG
;
Wei-Wei WANG
;
Wei LIU
Author Information
1. 310014,杭州市西溪医院
- Keywords:
Hepatitis B surface antigens;
DNA;
Liver cirrhosis
- From:
Chinese Journal of Experimental and Clinical Virology
2013;27(1):44-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of serum hepatitis B surface antigen (HBsAg)level and hepatic tissue pathological staging in the chronic hepatitis B infected persons.Methods Collect the clinical data of 272 cases who are HBsAg-positive more than 6 months and accepted hepatic biopsy in our hospital.Detect serum HBsAg quantification,ALT,HBV DNA,complete blood count,hepatic tissue pathological staging,grouping the cases according to the stage of inflammation and the fibrosis degree respectively.Observe serum HBsAg quantification,HBV DNA and the stage of inflammation and the fibrosis degree.Analyse the correlation between HBsAg quantification and HBV DNA.Results The correlation of serum HBsAg level and HBV DNA is notable.Serum HBsAg level is a variable affecting hepatic tissue pathological stage significantly.Conclusions Serum HBsAg level is a marker having higher specificity and sensitivity to diagnose the hepatic fibrosis.
