Influence of non-sodium restricted diet with diuretics on plasma rennin, renal blood flow and in patients with cirrhotic ascites
10.3760/cma.j.issn.1003-9279.2013.01.016
- VernacularTitle:限钠与不限钠对肝硬化患者肾素、肾血流量及腹水的影响
- Author:
Yin-Fang ZHU
1
;
Xi-Bing GU
;
Hong-Ying ZHU
;
Xiao-Juan YANG
;
Dong WANG
;
Ping YU
Author Information
1. 无锡市传染病医院
- Keywords:
Liver cirrhosis;
Ascites;
Food,folmulated;
Renin;
Renal blood flow,effective
- From:
Chinese Journal of Experimental and Clinical Virology
2013;27(1):50-53
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore influence of sodium restricted diet and non-sodium restricted diet on plasma rennin (PRA),angiotensin Ⅱ (AII),ALD,renal blood flow (RBF) and subside of ascites in patients with cirrhotic ascites.Methods Eighty cases of hepatitis B with cirrhotic ascites were randomly divided into sodium restricted diet group and non-sodium restricted diet group.39 cases were in non-sodium restricted diet group,taking sodium chloride 6500-8000 mg daily; 41 cases were in sodium restricted diet group,taking sodium chloride 5000 mg daily.Both groups received diuretics furosemide and spironolactone.Blood sodium,urine sodium,PRA,AII,ALD,RBF ascites subsiding were compared after treatment.Results In non-sodium restricted diet group,blood sodium and urine sodium increased 10 days after treatment compared with those before treatment,and compared with those of sodium restricted diet group 10 days after treatment,P ＜ 0.01.RBF increased compared with that before treatment,and compared with that of sodium restricted diet group 10 days after treatment,P ＜ 0.01.Renal damage induced by low blood sodium after treatment was less in non-sodium restricted diet group than that in sodium restricted diet group,P ＜0.05.Ascites disappearance upon discharge was more in sodium restricted diet group than that in nonsodium restricted diet group,P ＜0.01.Time of ascites disappearance was shorter in non-sodium restricted diet group than that in sodium restricted diet group,P ＜ 0.01.Conclusion Compared with sodium restricted diet,while using diuretics of both groups,non-sodium restricted diet can increase level of blood sodium,thus increasing excretion of urine sodium and diuretic effect.It can also decrease levels of PRA,AII and ALD,increase renal blood flow and prevent renal damage induced by low blood sodium and facilitate subsiding of ascites.
