Efficacy of Peg-interferon alpha-2a combinated with entecavir on HBeAg positive chronic hepatitis B patients with high serum hepatitis B viral loads.
- Author:
Wen ZENG
1
;
Jing YUAN
;
Ying-Xia LIU
;
Ying ZHANG
;
Sha-Xi LI
;
Si-Min YAO
;
Yi-Min LIN
;
Chuan-Tie CHEN
;
Mei-Fen ZHAO
;
Jing LIU
;
Yan LIU
;
Bo-Ping ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Antiviral Agents; administration & dosage; Drug Therapy, Combination; Guanine; administration & dosage; analogs & derivatives; Hepatitis B e Antigens; blood; Hepatitis B, Chronic; drug therapy; virology; Humans; Interferon-alpha; administration & dosage; Polyethylene Glycols; administration & dosage; Recombinant Proteins; administration & dosage; Viral Load
- From: Chinese Journal of Experimental and Clinical Virology 2013;27(2):115-118
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study aimed at evaluating the efficacy and safety of a combination treatment of entecavir and Peginterferon alpha-2a for HBeAg positive chronic hepatitis B patients with high serum hepatitis B viral loads.
METHODS60 treatment-naive HBeAg-positive CHB patients with high serum hepatitis B viral loads were enrolled and randomly divided into three groups: group A received Peginterferon alpha-2a monotherapy for 48 weeks (n = 20); group B received entecavir monotherapy for more than 48 weeks (n = 20); group C received Peginterferona alpha-2a combined with entecavir for 12 weeks, then Peginterferon alpha-2a monotherapy for 36 weeks (n = 20). Virological response, ALT normalization, HBeAg and HBsAg seroclearance rate were analysed at the end of 4, 12 and 24 weeks after the treatment.
RESULTSThe ratio of undetectable hepatitis B virus (HBV) DNA were 50% and 10%, 95% and 25% and 100% and 30% in group C and group A respectively, 50% and 20%, 95% and 75% and 100% and 90% in group C and group B respectively at the end of 4, 12 and 24 weeks of treatment. The differences were significant between group C and A (Z = -4.6, P < 0.001), group C and B (Z = -2.53, P = 0.0114). ALT normalization rate was significantly lower in group A than that of group C (Z = -2.63, P = 0.0086). HBeAg levels declined more in group C than the other two groups after 24 weeks of treatment.
CONCLUSIONSFor HBeAg positive chronic hepatitis B patients with high serum hepatitis B viral loads, combination treament of Peginterferon alpha-2a with entecavir is more effective than Peginterferon alpha-2a monotherapy in virologic response and ALT normalization after 24 weeks of treatment.
