HBV genotype and liver histology effect of peginterferon α treatment of HBeAg-position chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2013.03.011
- VernacularTitle:HBV基因型及肝脏组织学对聚乙二醇干扰素α治疗HBeAg阳性慢性乙型肝炎疗效的影响
- Author:
Chuan-Tong LU
1
;
Guo-Sheng GAO
;
Hua-Dong YAN
;
Yao-Ren HU
Author Information
1. 315010,宁波市卫生信息中心
- Keywords:
Interferon-alpha;
Hepatitis B e antigens;
Genotype;
Histology;
Hepatitis B,chronic
- From:
Chinese Journal of Experimental and Clinical Virology
2013;27(3):193-195
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of PEG-interferon α (PEG-IFN α) treatment of HBeAg-positive chronic hepatitis B and HBV genotypes and liver tissues effect of HBeAg seroconversion.Methods 54 cases confirmed by liver biopsy,genotype clear HBeAg positive chronic hepatitis B (CHB) patients according to body weight,respectively,subcutaneous injection of PEG-IFN-α2a 135 μg or 180 μg,or PEG-IFN-α2b 50 μg,80 μg or 100 μg once weekly treatment for 48 weeks and followed for 24 weeks after discontinuation.Statistics of HBeAg seroconvertion,HBV genotypes and liver histology e antigen seroconversion after the end of treatment.Results 54 patients were followed up at the end of HBeAg seroconversion rate was 29.63％ (16/54).Genotype B patients with HBeAg seroconversion rate was 35.29％,27.03％ higher than the C-type patients,but the difference was not statistically significant (x2 =0.382,P =0.537).Inflammation of the liver activity highter(＞ G2),the degree of fibrosis heavier(＞ S1)HBeAg seroconversion rate (50.00％ vs.25.00％,40.90％ vs.21.88％),but were not statistically significant(x2 =1.391、1.444,P =0.238、0.229).Activity of HBV genotype,liver inflammation,liver fibrosis and other factors by multivariate Logistic regression analysis,only liver inflammation activity of the important factors of HBeAg seroconversion.Conclusion Important factors,liver inflammation activity of PEG-interferon αt treatment of HBeAg-position chronic hepatitis B patients and HBV genotypes and liver fibrosis may be of little significance.
