Value of high risk human papilloma virus detection in screening and diagnosing cervical lesion in littoral of Zhejiang province
10.3760/cma.j.issn.1003-9279.2013.03.018
- VernacularTitle:浙江沿海地区宫颈病变患者中高危型HPV检测及其临床价值
- Author:
Jun ZHU
1
;
Ying LIN
;
Hai-Bo RUAN
;
Xia-Hui ZHANG
;
Qian YANG
Author Information
1. 浙江省温岭市第一人民医院
- Keywords:
Cervix diseases;
Papilloma virus,human;
Hybridization
- From:
Chinese Journal of Experimental and Clinical Virology
2013;27(3):212-214
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the infection of high-risk human papiliomavirus(HR-HPV) in cervical lesion wome,and evaluate the significance of high-risk human pappilomavirus detection by hybrid capture Ⅱ (HV-Ⅱ) in screening and diagnosing cervical lesion,especially high grade cervical intraepithelial neoplasia(CIN).Methods A series of 1130 patients of cervical lesion were preliminarily diagnosed by cervical cytological examination,HR-HPV detection by HC-Ⅱ,colposcopy and biopsy under the colposcopy between June 2009 and December 2008,including 212 CIN Ⅰ and(or)condyloma(CIN Ⅰ/HPV Ⅰ),442 CIN Ⅱ/Ⅲ,28 invasive cervical cancer.cervical cytological examination is by thin prep liquid-based cytology test(TCT),and HR-HPV detection is by HC-Ⅱ.Results In 1130 cases the positive of HR-HPV was 65.84％ (744/1130).Unusual cytology result were 862 cases,with 356 ASCUS,84 ASCH,216 LSIL,184HSIL and 22 cancer.The number of biopsy ≥ CINI/HPVI was 682,positive rate of HR-HPV was 78.59％ (536/682).In screening CIN Ⅱ or above,sensitivity,specificity,PPV and NPV of TCT were 88.94％,32.73％,48.49％,80.60％,ofHR-HPV DNA detectiort by HC-Ⅱ were 90.21％,51.82％,57.14％,88.14％,and of HR-HPV detection combined with cytology were 97.45％,22.42％,47.22％,92.50％.Conclusion The infection rate of HR-HPV in cervical lesions is higher in each age group.Infection rate of HR-HPV is ascending with serious degree of cervical lesion.HR-HPV detection by HC-Ⅱ is an important method in screening cervical lesion.HR-HPV detection is a viable option in the management of women with ASCUS and LSIL of TCT,with higher sensitivity and NPV.
