The study of the expression of TCR BV CDR3 family in fulminant hepatitis B patients.
- Author:
Wen-Juan SHI
1
;
Hong WAN
2
;
Jian ZHOU
2
;
Li WEI
2
;
Zheng-Mao YANG
2
;
Zhao-Xun WANG
2
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Case-Control Studies; Complementarity Determining Regions; chemistry; genetics; immunology; Female; Hepatitis B; genetics; immunology; virology; Humans; Male; Middle Aged; Receptors, Antigen, T-Cell; chemistry; genetics; immunology; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2013;27(4):241-243
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of TCR BV CDR3 family in fulminant hepatitis B (FHB) patients.
METHODSTotally 28 patients with fulminant hepatitis B (FHB) (FHB group), who were treated in our hospital from Oct. 2010. to Mar. 2012, and 20 healthy controls( HC group) were included in the study. PBMCs were isolated from anticogulated blood, and RT-PCR was used to detect the levels of TCR BV CDR3 family in the 2 groups.
RESULTSThe levels of DeltaCt1, DeltaCt12 and DeltaCt20 in FHB group were higher than those in HC group (P < 0.05); The levels of DeltaCt5, DeltaCt7, DeltaCt13, DeltaCt14, DeltaCt15, DeltaCt22, DeltaCt23 in FHB group were lower than those in HC group (P < 0.05).
CONCLUSIONSThe result indicates that cellular immunology is involved in the pathogenesis of the liver inflammation process of FHB.
