The study of the expression of TCR BV CDR3 family in fulminant hepatitis B patients

VernacularTitle:重型乙型肝炎患者T细胞受体BV CDR3家族表达水平分析
Author: Wen-Juan SHI ¹ ; Hong WAN ; Jian ZHOU ; Li WEI ; Zheng-Mao YANG ; Zhao-Xun WANG
Author Information

1. 730046,兰州市第二人民医院感染科
Keywords: Hepatitis B; T-Lymphocytes
From: Chinese Journal of Experimental and Clinical Virology 2013;27(4):241-243
CountryChina
Language:Chinese
Abstract: Objective To study the expression of TCR BV CDR3 family in fulminant hepatitis B (FHB) patients.Methods Totally 28 patients with fulminant hepatitis B (FHB) (FHB group),who were treated in our hospital from Oct.2010.to Mar.2012,and 20 healthy controls(HC group) were included in the study.PBMCs were isolated from anticogulated blood,and RT-PCR was used to detect the levels of TCR BV CDR3 family in the 2 groups.Results The levels of ΔCt1,ΔCt12 and ΔCt20 in FHB group were higher than those in HC group (P ＜ 0.05) ; The levels of ΔCt5,ΔCt7,ΔCt13,ΔCt14,ΔCt15,ΔCt22,ΔCt23 in FHB group were lower than those in HC group (P ＜ 0.05).Conclusions The result indicates that cellular immunology is involved in the pathogenesis of the liver inflammation process of FHB.