Research of the relationship of ubiquinone and beclin-1 and liver mitochondria.
- Author:
Fang XIE
1
;
Chao ZHANG
1
;
Yue-Ke ZHU
1
;
Hui LIU
1
;
Xue-Mei LIU
1
;
Lin JIA
1
;
Ke-Fei WANG
1
;
De-Xi CHEN
1
;
Qing-Hua MENG
1
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis Regulatory Proteins; genetics; metabolism; Autophagy; Beclin-1; Humans; Liver Failure, Acute; genetics; metabolism; physiopathology; Male; Mitochondria, Liver; metabolism; Rats; Rats, Sprague-Dawley; Ubiquinone; analogs & derivatives; metabolism
- From: Chinese Journal of Experimental and Clinical Virology 2013;27(4):250-252
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study whether CO-Q10 can protect liver injury caused by acute on chronic liver failure (ACLF) by autophagy.
METHODSRats were separated into three groups: control group, acute on chronic liver failure (ACLF) and intervenient group, liver tissues were observed by optical microscopy and electron microscopy. The levels of Beclin-1 expression were determined by real-time PCR. And Western Blot.
RESULTSAreas of necrosis detected in intervenient group were alleviated than in ACLF significantly. Most mitochondrias had been degradated in ACLF group while alive in intervenient group. Real-time PCR and Western Blot revealed level of beclin-1 in ACLF was lower than control and intervenient group.
CONCLUSIONIntervenient group may ameliorate rat liver injury by promoting autophagy.
