Clinical research of early, enough methylprednisone combined with immunoglobulin in treatment of severe hand-foot-mouth disease

VernacularTitle:早期、足量甲基强的松龙联合丙种免疫球蛋白治疗重症手足口病的临床研究
Author: Ming JIANG ¹ ; Xing-Chuan WANG
Author Information

1. 中国人民解放军第一八一医院
Keywords: Hand-foot-mouth disease; Corticosteroids; Immunoglobulin
From: Chinese Journal of Experimental and Clinical Virology 2013;27(5):363-365
CountryChina
Language:Chinese
Abstract: Objective To study the efficacy of early,enough methylprednisone combined with immunoglobulin in treatments of severe hand-foot-mouth disease.Methods 568 patients of severe handfoot-mouth disease involved were randomized into group A and group B.Patients of both groups all accepted symptomatic treatment,supportive therapy and the treatment of control intracranial pressure.And patients in group A received the treatment of early,enough methylprednisone combined with immunoglobulin,whereas patients in group B received conventional therapy.Results Curative rate of group A was better than that of group B,otherwise incidence rate of critical illness was less than that of group B.The control time of fever,erythra,neurological symptoms,features of pneumonia and increased leukocyte of group A was shorter than that of group B,and no more recent or Long-term treatment-related adverse reaction in group A.Conclusion Early,enough methylprednisone combined with immunoglobulin is effective,safe in treating severe handfoot-mouth disease,and worthy to recommand its clinical use.