Therapeutic Effects of Periocular Injection of Triamcinolon Acetonide in Patients with Thyroid-Associated Ophthalmopathy.
10.3341/jkos.2011.52.7.788
- Author:
Jong Eul KIM
1
;
Jung Won PARK
;
Jae Kap CHO
;
Kyung Chul YOON
Author Information
1. Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea. kcyoon@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Periocular injection;
Thyroid-associated ophthalmopathy;
Triamcinolone
- MeSH:
Atrophy;
Diplopia;
Exophthalmos;
Eye;
Graves Ophthalmopathy;
Humans;
Hyperemia;
Injections, Intraocular;
Intraocular Pressure;
Muscles;
Orbit;
Subcutaneous Fat;
Thyroid Gland;
Triamcinolone;
Triamcinolone Acetonide;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2011;52(7):788-793
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The present study investigated the therapeutic effects of periocular triamcinolone acetonide injections to treat inflammatory signs in patients with severe acute thyroid-associated ophthalmopathy. METHODS: Twenty-two patients with symptoms of severe acute thyroid ophthalmopathy were enrolled in the present study. The patients received four doses of 20 mg of triamcinolone acetonide via periocular injection into the inferotemporal orbital quadrant every 2 weeks. The changes in visual acuity, intraocular pressure, eye ball motility, exophthalmos, thickness of extraocular muscles, clinical activity score and NOSPECS score were measured. RESULTS: Eighteen of 22 patients (81.8%) showed improvement in soft tissue swelling, ten patients (45.5%) showed improvement in conjunctival hyperemia and one patient showed improvement of ocular motility. Clinical activity score and NOSPECS score had significant improvements. No patient had changes in visual acuity, intraocular pressure, diplopia, proptosis or thickness of extraocular muscles. An ocular adverse effect was found in one patient, who had subcutaneous fat atrophy at the injection site. CONCLUSIONS: In patients with severe acute thyroid ophthalmopathy, periocular triamcinolone acetonide injection can be effective to improve acute inflammatory symptoms, without significant adverse effects.
