Analysis of Factors Affecting Corneal Endothelial Cell Loss after Penetrating Keratoplasty.
10.3341/jkos.2011.52.7.807
- Author:
Tai Kyong KIM
1
;
Yong Soo BYUN
;
Man Soo KIM
Author Information
1. Department of Ophthalmology and Visual Science, The Catholic University of Korea School of Medicine, Seoul, Korea. mskim@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Donor age;
Endothelial cell;
Glaucoma;
Penetrating keratoplasty;
Trephine diameter
- MeSH:
Corneal Endothelial Cell Loss;
Endothelial Cells;
Eye;
Glaucoma;
Graft Rejection;
Humans;
Keratoconus;
Keratoplasty, Penetrating;
Ophthalmic Solutions;
Risk Factors;
Tissue Donors
- From:Journal of the Korean Ophthalmological Society
2011;52(7):807-815
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the factors affecting corneal endothelial cell loss after penetrating keratoplasty in a long-term follow-up. METHODS: Donor age, post-mortem time, storage time, underlying disease, elevation of IOP after surgery, underlying glaucoma, and trephine size were analyzed in 76 eyes. Postoperative corneal endothelial density was measured after 1, 3, 6, and 12 months. Patients who experienced graft rejection were excluded. RESULTS: Donor age and endothelial loss were correlated in all patients (t-value = 1.98); however, post-mortem time and storage time were not statistically significant (t 2 < 2). Endothelial cell loss was more severe in the bullous keratopathy patient group than it was in the keratoconus patient group, but this difference was not statistically significant (p-value = 0.154). The number of anti-glaucomatous eye drops showed positive correlation with the declining rate of endothelial cells (t-value = 1.975). Existence of glaucoma diagnosed before surgery did not statistically influence endothelial cell loss. Additionally, in the bullous keratopathy patient group, an inverse correlation between endothelial cell loss and trephine diameter was observed (t-value = -2.859). CONCLUSIONS: Old donor age, small trephine size in bullous keratopathy, and post-operative IOP elevation are risk factors for increased endothelial cell loss following penetrating keratoplasty.
