Significance of the examination of path between eosinophils in peripheral blood and marrow stem cells for evaluating the effect of hormone therapy in patients with allergic rhinitis
10.3321/j.issn:1673-0860.2008.07.003
- VernacularTitle:变应性鼻炎患者外周血嗜酸粒细胞-骨髓干细胞通路指标检测在激素治疗评价中的意义
- Author:
Hui ZHANG
1
;
Da-Liang ZHANG
;
Jing-Jie ZHAO
;
Jun-Li LIU
;
Xian-Liang FAN
;
Cheng-Hao GUO
Author Information
1. 山东大学附属第二医院
- Keywords:
Rhinitis,allergic,perennial;
Antigens,CD34;
Interleukin-5;
Eosinophils
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2008;43(7):490-493
- CountryChina
- Language:Chinese
-
Abstract:
Objective By means of the detection of the numbers of CD34+ cells and eosinophils(EOS),and the level of IL-5 in peripheral blood from normal controls and patients with allergic rhinitis pre-or post-treatment.the role of EOS-stem cells paths for treatment effect in allergic rhinitis(AR)was studied so as to find the convenient and quick indicators which could be used to evaluate the clinical therapeutic effect and adiust the methods of the hormone therapy.Methods There were 2 groups.(1)experimental group:44 patients,including 24 males and 20 females with a age range of 7 to 68 years old.The patients received the treatment of flutieasone spurt for four weeks.(2)Control group:30 cases,from normal health examination.The EOS numbers,CD34+ cell numbers and the IL-5 level were examined in control group as well as before and after therapy in experimental group.Results The IL-5 level and CD34+ numbers before thearpy in experimental group were(88.25±33.47)ng/L、(9.24±2.15)/105,significantly higher than that after thearpy and experimental group which were(44.34±16.32)ng/L,(6.31±1.83)/105 and(31.24±8.43)ng/L,(3.47±1.32)/105 respectively.The IL-5 level was positively correlated with the CD34+ number pre-and post treatment in experimental group(r=0.64,P＜0.01;(r=0.61,P＜0.01).The EOS number was positively correlated with the level of IL-5(r=0.64,P＜0.01).Conclusions IL-5 and CD34+ cells can be regarded as indicators to evaluate the therapeutic effect.The EOS、CD34+ cells and the level of IL-5 in the peripheral blood are correlated with the pathogenesis of AR,suggesting that there is a related path between the local nasal tissue of AR patients and the marrow.
