Association of single nucleotide polymorphisms of GATA3 with allergic rhinitis phenotypes in Chinese
10.3321/j.issn:1673-0860.2008.07.004
- VernacularTitle:转录因子GATA3单核苷酸多态性与变应性鼻炎的关系
- Author:
Xiang-Dong WANG
1
;
Luo ZHANG
;
Hong DUAN
;
Wen-Yu SHE
;
Yan ZHAO
;
Shuo LIU
;
De-Min HAN
Author Information
1. 首都医科大学附属北京同仁医院
- Keywords:
Rhinitis,allergic,seasonal;
GATA3 transcriotion factor;
Polymorphism,single nucleotide;
Immunoglobulin E
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2008;43(7):494-498
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between single nucleotide polymorphisms(SNP)of GATA3 and Chinese with allergic rhinitis.Methods This study included 109 patients with allergic rhinitis and 112 healthy control people.SNP of two loci with restriction fragment length polymorphism was detected,rs1269486 at promoter region and rs2229360 located 92 bp downstream of STOP codon.Total IgE and specific IgE of Der P and Der f with different genotypes of the two loci were compared.Results There was SNP at both loci of rs1269486 and rs2229360.The genotypes of rs1269486 were GG,GA and AA,and the genotypes of rs2229360 were CC,CT and TT.The frequency of genotype GG and allele G in patient group was significantly higher than that in control group(X2=13.75,P＜0.01;X2=12.91,P＜0.01),and the frequency of genotype GA and allele A in patient group was significantly lower than that in control group(X2=11.90,P＜0.01;X2=12.91,P＜0.01).There were no significant differences between patient group and control group for the frequencies of genotypes and alleles at rs2229360(P＞0.05).The haplotype frequency of GC in patient group was significantly higher than that in control group(X2=114.59,P＜0.01),and the haplotype frequency of AC in patient group was significantly lower than that in control group (X2=87.52,P＜0.01).There was no significant difference of the levels of serum total IgE and specific IgE to Der p and Der f with the genotypes at the two loci(P＞0.05).Conclusions The SNP at rs1269486 of GATA3 is associated with allergic rhinitis in Chinese.
