Correlation between the vascular endothelial growth factor C expression and lymph node metastasis in human nasopharyngeal carcinoma
10.3321/j.issn:1673-0860.2008.07.010
- VernacularTitle:血管内皮生长因子在鼻咽癌组织中的表达及其与淋巴转移的关系
- Author:
Jun SUI
1
;
Xiao-Juan CAO
;
Xiao-Jiang LI
Author Information
1. 昆明医学院附属第三医院
- Keywords:
Vascular endothelial growth factor C;
Nasopharyngeal neoplasms;
Lymphangiogenesis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2008;43(7):524-528
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of vessel endothelial growth factorc(VEGF-C)and microlymphatic vessel density(MLVD)and probe the relationship between lymphangiogenesis and lymph node micrometastasis in nasopharyngeal carcinoma.Methods The expression of VEGF-C,was evaluated in 58 cases with nasopharyngeal carcinoma and 20 samples of nasopharyngitis tissues by immunohistochemical staining SP methods.The MLVD in tumor was counted by immunostaining with the specific antibody lymphatic vessel endothelial hyaluronic acid receptor 1 and analyzed with clinieopathologic parameters.Results The positive rate of VEGF-C was 84.5% and 15.0% respectively in nasopharyngeal carcinoma and nasopharyngitis tissues,there was significant difference between them(X2=32.309,P＜0.01).The microlymphatic vessel density was(28.6±6.2)pieces per field and(10.5±3.0)pieces per field respectively in nasopharyngeal carcinoma and nasopharyngitis tissues,there was significant difference between them(t=12.491,P＜0.01).The expression of VEGF-C and the MLVD were significantly higher in nasopharyngeal carcinoma and in lymph node mesastasis group than in no-metastasis group.The expression of VEGF-C was positively correlated with MLVD(t=3.512,P＜0.01),lymph node metastasis(X2=7.715,P＜0.01,r=0.712)and clinical stage(X2=4.250,P＜0.05,r=0.481).Conclusions In nasopharyngeal carcinoma,the expression rate of VEGF-C was high.VEGF-C expression was positively correlated with MLVD and lymph node metastasis and tumor staging.It was explained that VEGF-C attached itself to the emergence and infihration and transfer of NPC.There was close correlation between the expression of VEGF-C and MLVD.It was explained that the expression of VEGF-C in NPC was correlated to neoplasm lymphangiogenesis and that VEGF-C played a vital role in the progression of NPC.VEGF-C Was likely to a potential target of antieareer therapy.
