An experimental study of polypropylerie combined with flap for trachea reconstruction
10.3321/j.issn:1673-0860.2008.07.012
- VernacularTitle:聚丙烯网状材料与颈前皮瓣联合重建气管的实验研究
- Author:
Xue-Ning ZHAO
1
;
Bo CONG
;
Da-Yu LIU
;
Da-Peng LEI
;
Ping YE
;
Kun LIANG
;
Lei YAO
;
Zhong-Hua ZHANG
;
Xin-Liang PAN
Author Information
1. 山东大学齐鲁医院
- Keywords:
Tracheal diseases;
Reconstructive surgical procedures;
Models,animal;
Prostheses and implants;
Polyprupylenes;
Stents
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2008;43(7):533-536
- CountryChina
- Language:Chinese
-
Abstract:
Objective Canine model established for tracheal defect reconstruction,to investigate the outcome of tracheal reconstruction with combination of polypropynene and flap.Methods About 3.5 to 4 centimeter cervical trachea was resected and replaced with artificial trachea made from monofilament knitted polypropylene and surgical flap.Covered stent Was implanted postoperatively.Survival period and quality of life were recorded,brunchofibroscopy,X-ray films and HE sections were perfomed.Results Six dogs survived well and another two died.The causes of death were respiratory failure in 1 and infection in another.Stenosis of anastomosis in 1 Was recorded during survival period.The dogs started drinking and eating on the second postoperative day,no dyspnea Was found.The animals were sacrificed at 2,4,8 weeks and 6 months after surgery.Soft tissue growth Was found in polypropynene net 2 weeks after surgery and more at 4 weeks.The polypropynene net was covered completely with soft tissue at 8 weeks and 6 months postoperatively.the hardness and sustentation degree were enhanced following the growth and fibrosis of soft tissue.The squamous epithelium and columnar epithelium were ohserved healing well by HE staining method.Conclusions One-stage operative artificial trachea made from monofilament knitted polypropylene which has good histocompatibility and surgical flap is the closer artificial trachea to native trachea.It has a promising prospect in clinical use.
