Clinical efficacy of the fine needle aspiration of the cell block in the diagnosis of parotid gland masses.

Hong Chen; Qingquan Fang; Jinhua TU

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Clinical efficacy of the fine needle aspiration of the cell block in the diagnosis of parotid gland masses.

Author: Hong CHEN ¹ ; Qingquan FANG ² ; Jinhua TU ³
Author Information

1. Pharmaceutical Department, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
2. Dept. of Pathology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
3. Dept. of Pathology, The
Publication Type:Journal Article
Keywords: cell block; fine needle aspiration; mass; molecular marker; parotid gland
MeSH: Adenoma, Pleomorphic; Biopsy, Fine-Needle; Carcinoma, Adenoid Cystic; Cysts; Female; Humans; Male; Parotid Gland; Parotid Neoplasms; Personal Satisfaction; Staining and Labeling; Ultrasonics
From: West China Journal of Stomatology 2016;34(5):483-487
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the clinical significance of cell blocks obtained by ultrasound-guided fine needle aspiration in diagnosing parotid gland masses.
METHODSCell blocks were made in 285 parotid gland masses by ultrasound-guided fine needle aspiration. Diagnosis was conducted using the cell blocks. Non-tumor masses were subjected to conservative treatment, and cysts and tumors were treated with surgery. The cell block sections from masses with the diagnosis of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA) were applied to the detection of immunocytochemical staining for the stem cell factor receptor CD117.
RESULTSThe satisfaction rate of the specimen was 95.1% (271/285). The accuracy rate of the diagnosis was 94.5% (256/271), the sensitivity was 87.0% (67/77), and the specificity was 98.1% (157/160). The positive rate of CD117 in ACC was 95.2% (20/21), whereas that in PA was 20.3% (25/123). The positive rate of CD117 in ACC was higher than that in PA (P<0.01).
CONCLUSIONSThe use of cell blocks obtained from ultrasound-guided fine needle aspiration, together with molecular marker detection, has great significance in diagnosing parotid gland masses. .